How REVEAL™ Works

REVEAL is an informatics-based computational platform for the identification of unrecognized associations between compounds (natural products, small molecules) and their biological targets, as well as the prediction of new potential associations. The approach takes advantage of structural and functional information to identify chemical features of ligands that evolution has paired with biological targets. In another embodiment, REVEAL generates insights into the molecular mechanisms of target modulation by ligands. Collectively, the output from these analyses is used to inform a chemical design strategy tailored to a specific target.